Jennifer Aniston and Brad Pitt in 2005. Speculation has swirled in the press that while Pitt was married to Aniston, he engaged in an illicit affair with “Mr. & Mrs. Smith” co-star Angelina Jolie which fueled the split-up. Pitt and Jolie have since parented six children and have used their immeasurable fame and wealth to provide considerable support to humanitarian and political causes. But still, there was the affair. Jolie’s announcement of undergoing a preventive double mastectomy to lower her chances of developing breast cancer to under 5 percent in a Time magazine cover story brought genetic testing to the spotlight with Eric Topol, a geneticist and director of the Scripps Translational Science Institute referring to Jolie’s advocacy for wider accessibility for BRCA gene testing as a “moment that will propel genomic medicine forward.” But still, there was the affair. Pitt founded the Make It Right Foundation that organized housing professionals in New Orleans to finance and construct 150 sustainable, affordable new houses in New Orleans's Ninth Ward following the devastation caused by Hurricane Katrina. But still, there was the affair.
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